Seventy tornadoes break out in the central United States. Before the outbreak's end, Andover, Kansas, would record the year's only F5 tornado.

On April 26, 1991, a large tornado outbreak struck the central United States. The outbreak produced an F5 tornado that heavily damaged the town of Andover, Kansas, as well as numerous less destructive tornadoes throughout the region. The outbreak killed 21 people, 17 of which were from the Andover tornado.

A news team filming a tornado in the outbreak sought shelter under a highway overpass, causing a misconception that overpasses can provide adequate shelter during a tornado.