The Spanish military Villasur expedition is wiped out by Pawnee and Otoe warriors near present-day Columbus, Nebraska.

The Villasur expedition of 1720 was a Spanish military expedition intended to check New France's growing influence on the North American Great Plains, led by Lieutenant-General Pedro de Villasur. Pawnee and Otoe Indians attacked the expedition in Nebraska, killing 36 of the 40 Spaniards, 10 of their Indian allies, and a French guide. The survivors retreated to their base in New Mexico.