Pope Innocent VIII issues the Summis desiderantes affectibus, a papal bull that deputizes Heinrich Kramer and Jacob Sprenger as inquisitors to root out alleged witchcraft in Germany.

Pope Innocent VIII (Latin: Innocentius VIII; Italian: Innocenzo VIII; 1432 – 25 July 1492), born Giovanni Battista Cybo (or Cibo), was head of the Catholic Church and ruler of the Papal States from 29 August 1484 to his death. Son of the viceroy of Naples, Battista spent his early years at the Neapolitan court. He became a priest in the retinue of Cardinal Calandrini, half-brother to Pope Nicholas V (1447–55), Bishop of Savona under Pope Paul II, and with the support of Cardinal Giuliano Della Rovere. After intense politicking by Della Rovere, Cibo was elected pope in 1484. King Ferdinand I of Naples had supported Cybo's competitor, Rodrigo Borgia. The following year, Pope Innocent supported the barons in their failed revolt.

In March 1489, Cem, the captive brother of Bayezid II, the Sultan of the Ottoman Empire, came into Innocent's custody. Viewing his brother as a rival, the Sultan paid Pope Innocent not to set him free. The amount he paid to Pope Innocent was 120,000 crowns (an amount equal to all of the annual revenue to the Vatican) in addition to some holy relics and another sum of money to be paid annually. Any time the Sultan threatened war against the Christian Balkans, Innocent threatened to release his brother. On 28 January 1495 Cem was released by Innocent's successor Pope Alexander VI into the custody of King Charles's army, when some weeks later he died of possible poisoning but more likely pneumonia.