Karađorđe leads the First Serbian Uprising against the Ottoman Empire.

The First Serbian Uprising (Serbian: Prvi srpski ustanak, Serbian Cyrillic: ; Turkish: Birinci Srp Ayaklanmas) was an uprising of Serbs in the Sanjak of Smederevo against the Ottoman Empire from 14 February 1804 to 7 October 1813. Initially a local revolt against renegade janissaries who had seized power through a coup, it evolved into a war for independence (the Serbian Revolution) after more than three centuries of Ottoman rule and short-lasting Austrian occupations.

The janissary commanders murdered the Ottoman Vizier in 1801 and occupied the sanjak, ruling it independently from the Ottoman Sultan. Tyranny ensued; the janissaries suspended the rights granted to Serbs by the Sultan earlier, increased taxes, and imposed forced labor, among other things. In 1804 the janissaries feared that the Sultan would use the Serbs against them, so they murdered many Serbian chiefs. Enraged, an assembly chose Karaore as leader of the uprising, and the rebel army quickly defeated and took over towns throughout the sanjak, technically fighting for the Sultan. The Sultan, fearing their power, ordered all pashaliks in the region to crush them. The Serbs marched against the Ottomans and, after major victories in 180506, established a government and parliament that returned the land to the people, abolished forced labor, and reduced taxes.

Military success continued over the years; however, there was dissent between Karaore and other leadersKaraore wanted absolute power while his dukes, some of whom abused their privileges for personal gain, wanted to limit it. After the Russo-Turkish War ended and Russian support ceased, the Ottoman Empire exploited these circumstances and reconquered Serbia in 1813.

The Serbs were the first Christian population in Ottoman history to have risen up against the Sultan, their uprising ultimately became a symbol of the nation-building process in the Balkans, inspiring unrest among neighboring Balkan peoples.Although the uprising was unsuccessful, it resumed shortly with the Second Serbian Uprising in 1815.

Đorđe Petrović (Serbian Cyrillic: Ђорђе Петровић, pronounced [d͡ʑôːrd͡ʑe pětroʋit͡ɕ]), better known by the sobriquet Karađorđe (Serbian Cyrillic: Карађорђе, lit. 'Black George', pronounced [kârad͡ʑoːrd͡ʑe]; 16 November [O.S. 3 November] 1768 – 26 July [O.S. 14 July] 1817), was a Serbian revolutionary who led the struggle for his country's independence from the Ottoman Empire during the First Serbian Uprising of 1804–1813.

Born into an impoverished family in the Šumadija region of Ottoman Serbia, Karađorđe distinguished himself during the Austro-Turkish War of 1788–1791 as a member of the Serbian Free Corps, a militia of Habsburg and Ottoman Serbs, armed and trained by the Austrians. Fearing retribution following the Austrians' and Serb rebels' defeat in 1791, he and his family fled to the Austrian Empire, where they lived until 1794, when a general amnesty was declared. Karađorđe subsequently returned to Šumadija and became a livestock merchant. In 1796, the rogue governor of the Sanjak of Vidin, Osman Pazvantoğlu, invaded the Pashalik of Belgrade, and Karađorđe fought alongside the Ottomans to quash the incursion.

In early 1804, following a massacre of Serb chieftains by renegade Ottoman janissaries known as Dahis, the Serbs of the Pashalik rebelled. Karađorđe was unanimously elected to lead the uprising against the Dahis at an assembly of surviving chiefs in February 1804. Within six months, most of the Dahi leaders had been captured and executed by Karađorđe's forces, and by 1805, the final remnants of Dahi resistance had been crushed. Karađorđe and his followers demanded far-reaching autonomy, which Sultan Selim interpreted as but the first step towards complete independence. Selim promptly declared jihad against the rebels and ordered an army to march into the Pashalik. The Ottomans suffered a string of defeats at the hands of Karađorđe's forces. By 1806, the rebels had captured all the major towns in the Pashalik, including Belgrade and Smederevo, and expelled their Muslim inhabitants. Burdened by the demands of the Russo-Turkish War of 1806–1812, Selim offered the Serbs extensive autonomy, but Karađorđe refused in light of Russia's avowal to aid the rebels should they continue fighting.

Frequent infighting, together with Napoleon's invasion of Russia in 1812, weakened the rebels, and the Ottomans were able to reverse many of their gains. Karađorđe was forced to flee Serbia in October 1813 and Belgrade fell later that month, bringing the First Serbian Uprising to a close. He and his followers sought refuge in the Austrian Empire, but were arrested and detained. Despite Ottoman requests for his extradition, the Austrians handed Karađorđe over to the Russians, who offered him refuge in Bessarabia. There, he joined the Greek secret society known as Filiki Eteria, which planned to launch a pan-Balkan uprising against the Ottomans. Karađorđe returned to Serbia in secret in July 1817, but was killed shortly thereafter by agents of Miloš Obrenović, a rival rebel leader, who was concerned that Karađorđe's reappearance would cause the Ottomans to renege on the concessions they had agreed to following the Second Serbian Uprising of 1815. Karađorđe is considered the founder of the Karađorđević dynasty, which ruled Serbia in several intervals during the 19th and 20th centuries. His murder resulted in a violent, decades-long feud between his descendants and those of Obrenović, with the Serbian throne changing hands several times.