Major snowstorm paralyzes Midwestern United States, Milwaukee, Wisconsin and ties all-time record low temperature at −26 °F (−32.2 °C)

Milwaukee ( mil-WAW-kee), officially the City of Milwaukee, is the most populous city in the U.S. state of Wisconsin and the county seat of Milwaukee County. With a population of 577,222 at the 2020 census, Milwaukee is the 31st largest city in the United States, the fifth-largest city in the Midwestern United States, and the second largest city on Lake Michigan's shore behind Chicago.

It is the main cultural and economic center of the Milwaukee metropolitan area, the fourth-most densely populated metropolitan area in the Midwest. Milwaukee is considered a "Gamma " global city, as categorized by the Globalization and World Cities Research Network, with a regional GDP of over $102 billion in 2020.Today, Milwaukee is one of the most ethnically and culturally diverse cities in the U.S. However, it continues to be one of the most racially segregated, largely as a result of early-20th-century redlining. Its history was heavily influenced by German immigrants in the 19th century, and continues to be a center for German-American culture, specifically becoming well known for its brewing industry. In recent years, Milwaukee has been undergoing its largest construction boom since the 1960s. Major additions to the city since the turn of the 21st century include the Wisconsin Center, American Family Field, The Hop (streetcar system), an expansion to the Milwaukee Art Museum, Milwaukee Repertory Theater, the Bradley Symphony Center, and Discovery World, as well as major renovations to the UWMilwaukee Panther Arena. Fiserv Forum opened in late 2018, and hosts sporting events and concerts. Since 1968, Milwaukee has been home to Summerfest, one of the largest music festivals in the world. With regard to education, Milwaukee is home to the Medical College of Wisconsin, UW-Milwaukee, Marquette University, MSOE, and several other universities and colleges. The city is home to two major professional sports teams the Bucks and the Brewers. It is home to several Fortune 500 companies, including Northwestern Mutual, WEC Energy Group, Rockwell Automation, and Harley-Davidson.

The Midwestern United States, also referred to as the Midwest or the American Midwest, is one of four census regions of the United States Census Bureau (also known as "Region 2"). It occupies the northern central part of the United States. It was officially named the North Central Region by the Census Bureau until 1984. It is between the Northeastern United States and the Western United States, with Canada to its north and the Southern United States to its south.

The Census Bureau's definition consists of 12 states in the north central United States: Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, North Dakota, Ohio, South Dakota, and Wisconsin. The region generally lies on the broad Interior Plain between the states occupying the Appalachian Mountain range and the states occupying the Rocky Mountain range. Major rivers in the region include, from east to west, the Ohio River, the Upper Mississippi River, and the Missouri River. The 2020 United States census put the population of the Midwest at 68,995,685. The Midwest is divided by the Census Bureau into two divisions. The East North Central Division includes Illinois, Indiana, Michigan, Ohio, and Wisconsin, all of which are also part of the Great Lakes region. The West North Central Division includes Iowa, Kansas, Minnesota, Missouri, North Dakota, Nebraska, and South Dakota, several of which are located, at least partly, within the Great Plains region.

Chicago is the most populous city in the American Midwest and the third most populous in the United States. Chicago and its suburbs, together called Chicagoland, form the largest metropolitan area with 10 million people, making it the fourth largest metropolitan area in North America, after Greater Mexico City, the New York Metropolitan Area, and Greater Los Angeles. Other large Midwestern cities include (in order by population) Columbus, Indianapolis, Detroit, Milwaukee, Kansas City, Omaha, Minneapolis, Wichita, Cleveland, St. Paul, St. Louis, and Cincinnati. Large Midwestern metropolitan areas include Metro Detroit, Minneapolis–St. Paul, Greater St. Louis, Greater Cincinnati, the Kansas City metro area, the Columbus metro area, and Greater Cleveland.