The Archdiocese of Manila was made a diocese by a papal bull with Domingo de Salazar being its first bishop.

Domingo de Salazar (1512 4 December 1594) was a Catholic prelate who served as the first Bishop of Manila (157994) which was then newly-annexed to the Spanish Empire.

The Roman Catholic Archdiocese of Manila (Latin: Archidioecesis Manilensis; Filipino: Arkidiyosesis ng Maynilà; Spanish: Arquidiócesis de Manila) is the archdiocese of the Latin Church of the Catholic Church in Metro Manila, Philippines, encompassing the cities of Manila, Makati, San Juan, Mandaluyong, and Pasay. The cathedral church is a minor basilica located in Intramuros, which comprises the old city of Manila. The Blessed Virgin Mary, under the title Immaculate Conception, is the principal patroness.

The Archdiocese of Manila is the oldest diocese in the Philippines, created in 1579 as a diocese and elevated as a metropolitan archdiocese in 1595. Since its last territorial changes in 2003, the Archdiocese of Manila is the metropolitan see of the ecclesiastical province of the same name, which also include five dioceses encompassing most of the National Capital Region (Novaliches, Parañaque, Cubao, Kalookan, and Pasig) and four dioceses of its surrounding provinces of Cavite (Diocese of Imus), Rizal and Marikina City (Diocese of Antipolo), Bulacan and Valenzuela City (Diocese of Malolos), and Laguna (Diocese of San Pablo).

In addition, the Archdiocese also serves as the de facto overseer of the Military Ordinariate of the Philippines, as well as the Apostolic Vicariates of Puerto Princesa and Taytay in Palawan, all exempt dioceses of the Holy See (with the vicariates under the jurisdiction of the Congregation for the Evangelization of Peoples).

The archdiocese also owns and manages the following institutions located outside its own territorial jurisdiction: Mount Peace Retreat House (in Baguio City), Saint Michael Retreat House (in Antipolo City, Rizal), DZRV Radio Veritas 846 kHz (in Barangay Philam, Quezon City which is under the jurisdiction of the Diocese of Cubao), EDSA Shrine or the Shrine of Mary, Queen of Peace (in Barangay Ugong Norte, Quezon City) and Redemptoris Mater Missionary Seminary - Manila in Parañaque.

The archdiocese, under the name "Roman Catholic Archbishop of Manila," is a shareholder in the Bank of the Philippine Islands with 327,904,251 shares or 7.3 percent as of December 31, 2020.Since June 24, 2021, the metropolitan archdiocese is led by metropolitan archbishop Jose Advincula.