In Nashville, Tennessee, an inbound local train collides with an outbound express, killing 101 and injuring 171 people, making it the deadliest rail accident in United States history.

The Great Train Wreck of 1918 occurred on July 9, 1918, in Nashville, Tennessee, United States. Two passenger trains, operated by the Nashville, Chattanooga and St. Louis Railway ("NC&StL"), collided head-on, costing at least 101 lives and injuring an additional 171. It is considered the worst rail accident in U.S. history, though estimates of the death toll of this accident overlap with that of the Malbone Street Wreck in Brooklyn, New York, the same year.

The two trains involved were the No. 4, scheduled to depart Nashville for Memphis, Tennessee, at 7:00 a.m.; and the No. 1 from Memphis, about a half-hour late for a scheduled arrival in Nashville at 7:10 a.m. At about 7:20 a.m., the two trains collided while traversing a section of single track line known as "Dutchman's Curve" west of downtown Nashville, in the present-day neighborhood of Belle Meade. The trains were each traveling at an estimated 50 to 60 mph (80 to 100 km/h). The impact derailed them both, and destroyed several wooden cars.

An investigation by the Interstate Commerce Commission (ICC) attributed the cause of the accident to several factors, notably serious errors by the crew of train No. 4 and interlocking tower operators, all of whom failed to properly account for the presence of train No. 1 on the line. The ICC also pointed to a lack of a proper system for the accurate determination of train positions and noted that the wooden construction of the cars greatly increased the number of fatalities.

Nashville is the capital and most populous city of the U.S. state of Tennessee. It is the county seat of Davidson County and is located on the Cumberland River. With a population of 689,447 as of the 2020 U.S. census, Nashville is the 21st most-populous city in the United States and the fourth most populous city in the Southeastern United States.

Named for Francis Nash, a general of the Continental Army during the American Revolutionary War, the city was founded in 1779. The city grew quickly due to its strategic location as a port on the Cumberland River and, in the 19th century, a railroad center. Nashville seceded with Tennessee during the American Civil War; in 1862 it was the first state capital in the Confederacy to fall to Union troops. After the war, the city reclaimed its position and developed a manufacturing base.

Since 1963, Nashville has had a consolidated city-county government, which includes six smaller municipalities in a two-tier system. The city is governed by a mayor, a vice-mayor, and a 40-member metropolitan council; 35 of the members are elected from single-member districts, while the other five are elected at-large. Reflecting the city's position in state government, Nashville is home to the Tennessee Supreme Court's courthouse for Middle Tennessee, one of the state's three divisions.

A major center for the music industry, especially country music, Nashville is commonly known as "Music City". It is also home to numerous colleges and universities, including Tennessee State University, Vanderbilt University, Belmont University, Fisk University, Trevecca Nazarene University, and Lipscomb University. Nashville is sometimes referred to as "Athens of the South" due to the large number of educational institutions. The city is also a major center for the healthcare, publishing, banking, automotive, technology, and transportation industries. Entities with headquarters in the city include AllianceBernstein, Asurion, Bridgestone Americas, Captain D's, Hospital Corporation of America, LifeWay Christian Resources, Logan's Roadhouse, and Ryman Hospitality Properties.