The Indian Removal Act is passed by the U.S. Congress; it is signed into law by President Andrew Jackson two days later.

The Indian Removal Act was signed into law on May 28, 1830, by United States President Andrew Jackson. The law authorized the president to negotiate with southern (including Mid-Atlantic) Native American tribes for their removal to federal territory west of the Mississippi River in exchange for white settlement of their ancestral lands. The Act was signed by Andrew Jackson and it was strongly enforced under his administration and that of Martin Van Buren, which extended until 1841.The Act was strongly supported by southern and northwestern populations, but was opposed by native tribes and the Whig Party. The Cherokee worked together to stop this relocation, but were unsuccessful; they were eventually forcibly removed by the United States government in a march to the west that later became known as the Trail of Tears, which has been described as an act of genocide, because many died during the removals.