Santo Trafficante, Sr., Italian-American mobster (d. 1954)

Santo Trafficante Sr. (May 28, 1886 – August 11, 1954) was a Sicilian-born mobster, and father of the powerful mobster Santo Trafficante Jr.

Santo Trafficante Sr. gained power as a mobster in Tampa, Florida and ruled the Mafia in Tampa from the 1930s until his death in 1954. Trafficante was heavily involved in the operation of illegal bolita lotteries. During his reign, Trafficante was a well-respected boss with ties to Charles "Lucky" Luciano and Thomas Lucchese.

Trafficante died of stomach cancer on August 11, 1954; he was a member of L'Unione Italiana, and he was buried in L'Unione Italiana Cemetery in Ybor City. His son, Santo Trafficante Jr. subsequently took over the crime family.