Rahima Banu, a two-year-old girl from the village of Kuralia in Bangladesh, is the last known person to be infected with naturally occurring smallpox.

Rahima Banu Begum (Bengali: রহিমা বানু বেগম; born 16 October 1972) is the last known person to have been infected with naturally occurring Variola major smallpox, the more deadly variety of the disease.