The lowest sea-level pressure in the Western Hemisphere, and the highest reliably-measured non-tornadic sustained winds, are recorded in Hurricane Patricia, which strikes Mexico hours later, killing at least 13 and causing over $280 million in damages.

Hurricane Patricia was the strongest tropical cyclone on record worldwide in terms of wind speed and the second-most intense on record worldwide in terms of pressure, behind Typhoon Tip in 1979, with a minimum atmospheric pressure of 872 mbar (hPa; 25.75 inHg). Originating from a sprawling disturbance near the Gulf of Tehuantepec, south of Mexico, in mid-October 2015, Patricia was first classified a tropical depression on October 20. Initial development was slow, with only modest strengthening within the first day of its classification. The system later became a tropical storm and was named Patricia, the twenty-fourth named storm of the annual hurricane season. Exceptionally favorable environmental conditions fueled explosive intensification on October 22. A well-defined eye developed within an intense central dense overcast and Patricia grew from a tropical storm to a Category 5 hurricane in just 24 hours—a near-record pace. On October 23, the hurricane achieved its record peak intensity with maximum sustained winds of 215 mph (345 km/h). This made it the most intense tropical cyclone on record in the Western Hemisphere and the strongest globally in terms of one-minute maximum sustained winds.

Late on October 23, dramatic weakening ensued and Patricia made landfall near Cuixmala, Jalisco, with winds of 150 mph (240 km/h). This still made it the strongest landfalling Pacific hurricane on record. Patricia continued to weaken extremely quickly, faster than it had intensified, as it interacted with the mountainous terrain of Mexico. Within 24 hours of moving ashore, Patricia weakened into a tropical depression and dissipated soon thereafter, late on October 24.

The precursor to Patricia produced widespread flooding rains in Central America. Hundreds of thousands of people were directly affected by the storm, mostly in Guatemala. At least six fatalities were attributed to the event: four in El Salvador, one in Guatemala, and one in Nicaragua. Torrential rains extended into southeastern Mexico, with areas of Quintana Roo and Veracruz reporting accumulations in excess of 19.7 in (500 mm). Damage in Chetumal reached MX$1.4 billion (US$85.3 million).As a tropical cyclone, Patricia's effects in Mexico were tremendous; however, the affected areas were predominantly rural, lessening the number of people directly impacted. Violent winds tore roofs from structures and stripped coastal areas of their vegetation. Preliminary assessments indicated hundreds of homes to be destroyed; seven fatalities were linked to the hurricane directly or indirectly, including one during evacuations. Total damage from Patricia was estimated to be at least $462.8 million (2015 USD); the damage in Mexico alone was estimated to be in excess of MX$5.4 billion (US$325 million), with agriculture and infrastructure comprising the majority of losses. Flooding partially associated with remnant moisture from Patricia inflicted US$52.5 million in damage across Southern Texas.