Major Rudolf Anderson of the United States Air Force becomes the only direct human casualty of the Cuban Missile Crisis when his U-2 reconnaissance airplane is shot down over Cuba by a Soviet-supplied SA-2 Guideline surface-to-air missile.

The Cuban Missile Crisis, also known as the October Crisis of 1962 (Spanish: Crisis de Octubre), the Caribbean Crisis (Russian: , tr. Karibsky krizis, IPA: [kripskj krizs]), or the Missile Scare, was a 35-day (16 October 20 November 1962) confrontation between the United States and the Soviet Union, which escalated into an international crisis when American deployments of missiles in Italy and Turkey were matched by Soviet deployments of similar ballistic missiles in Cuba. Despite the short time frame, the Cuban Missile Crisis remains a defining moment in US national security and nuclear war preparation. The confrontation is often considered the closest the Cold War came to escalating into a full-scale nuclear war.In response to the presence of American Jupiter ballistic missiles in Italy and Turkey, the failed Bay of Pigs Invasion of 1961, and Soviet fears of a Cuban drift towards China, Soviet First Secretary Nikita Khrushchev agreed to Cuba's request to place nuclear missiles on the island to deter a future invasion. An agreement was reached during a secret meeting between Khrushchev and Cuban Prime Minister Fidel Castro in July 1962, and construction of a number of missile launch facilities started later that summer.

Meanwhile, campaigning for the 1962 United States elections was underway, and the White House denied charges for months that it was ignoring dangerous Soviet missiles 90 mi (140 km) from Florida. The missile preparations were confirmed when a US Air Force U-2 spy plane produced clear photographic evidence of medium-range R-12 (NATO code name SS-4) and intermediate-range R-14 (NATO code name SS-5) ballistic missile facilities.

When this was reported to President John F. Kennedy, he then convened a meeting of the nine members of the National Security Council and five other key advisers, in a group that became known as the Executive Committee of the National Security Council (EXCOMM). During this meeting, President Kennedy was originally advised to carry out an air strike on Cuban soil in order to compromise Soviet missile supplies, followed by an invasion of the Cuban mainland. After careful consideration, President Kennedy chose a less aggressive course of action, in order to avoid a declaration of war. After consultation with EXCOMM, Kennedy ordered a naval "quarantine" on October 22 to prevent further missiles from reaching Cuba. By using the term "quarantine", rather than "blockade" (an act of war by legal definition), the United States was able to avoid the implications of a state of war. The US announced it would not permit offensive weapons to be delivered to Cuba and demanded that the weapons already in Cuba be dismantled and returned to the Soviet Union.

After several days of tense negotiations, an agreement was reached between Kennedy and Khrushchev: publicly, the Soviets would dismantle their offensive weapons in Cuba and return them to the Soviet Union, subject to United Nations verification, in exchange for a US public declaration and agreement to not invade Cuba again. Secretly, the United States agreed with the Soviets that it would dismantle all of the Jupiter MRBMs which had been deployed to Turkey against the Soviet Union. There has been debate on whether or not Italy was included in the agreement as well. While the Soviets dismantled their missiles, some Soviet bombers remained in Cuba, and the United States kept the naval quarantine in place until November 20, 1962.When all offensive missiles and the Ilyushin Il-28 light bombers had been withdrawn from Cuba, the blockade was formally ended on November 20. The negotiations between the United States and the Soviet Union pointed out the necessity of a quick, clear, and direct communication line between the two superpowers. As a result, the MoscowWashington hotline was established. A series of agreements later reduced USSoviet tensions for several years, until both parties eventually resumed expanding their nuclear arsenals.

Rudolf Anderson Jr. (September 15, 1927 – October 27, 1962) was an American and United States Air Force major and pilot. He was the first recipient of the Air Force Cross, the U.S. military's and Air Force's second-highest award and decoration for valor. The only U.S fatality by enemy fire during the Cuban Missile Crisis, Anderson died when his U-2 reconnaissance aircraft was shot down over Cuba. He had previously served in Korea after the Korean War ended.