Santiago, Chile, is destroyed by indigenous warriors, led by Michimalonco.

Michima Lonco (fl. mid-16th century) (michima means "foreigner" and lonco means "head" or "chief" in Mapudungun language) was a Picunche chief said to be a great warrior, born in the Aconcagua Valley and educated in Cusco by the Inca Empire. He presented himself to the Spaniards, naked and covered by a black pigmentation.On September 11, 1541, Michimalonco attacked the newly founded Spanish settlement of Santiago, Chile after seven caciques were taken hostage by Spaniards following an uprising. Michimalonco was said to lead 8,000 to 20,000 men. The defense of the outnumbered town was led by Ins de Surez, a female conquistador, while commander Pedro de Valdivia was elsewhere. Much of the town was destroyed when Surez decapitated one of the caciques herself and had the rest decapitated to surprise the natives. The natives were then driven off by the Spanish.

After fighting the Spaniards, he fled to the Andes mountain valleys. There he hid for a couple of years but feeling homesick he came back to the valley and allied his forces with the Spaniards and went to fight the Mapuches on the south. He was reputedly raised in Cuzco and acquired a Quechua accent when speaking his native language, therefore he was named the "Foreigner Chief".

Santiago (, US also ; Spanish: [sanˈtjaɣo]), also known as Santiago de Chile, is the capital and largest city of Chile as well as one of the largest cities in the Americas. It is the center of Chile's most densely populated region, the Santiago Metropolitan Region, whose total population is 8 million, of which more than 6 million live in the city's continuous urban area. The city is entirely in the country's central valley. Most of the city lies between 500–650 m (1,640–2,133 ft) above mean sea level.

Founded in 1541 by the Spanish conquistador Pedro de Valdivia, Santiago has been the capital city of Chile since colonial times. The city has a downtown core of 19th-century neoclassical architecture and winding side-streets, dotted by art deco, neo-gothic, and other styles. Santiago's cityscape is shaped by several stand-alone hills and the fast-flowing Mapocho River, lined by parks such as Parque Forestal and Balmaceda Park. The Andes Mountains can be seen from most points in the city. These mountains contribute to a considerable smog problem, particularly during winter, due to the lack of rain. The city outskirts are surrounded by vineyards and Santiago is within an hour of both the mountains and the Pacific Ocean.

Santiago is the cultural, political and financial center of Chile and is home to the regional headquarters of many multinational corporations. The Chilean executive and judiciary are located in Santiago, but Congress meets mostly in nearby Valparaíso. Santiago is named after the biblical figure St. James. The city will host the 2023 Pan American Games.