The United Kingdom's MI6 Secret Intelligence Service building is attacked by individuals using a Russian-built RPG-22 anti-tank missile. The perpetrators remain unidentified.

On Wednesday 20 September 2000, the Real Irish Republican Army (RIRA) carried out an attack on MI6's SIS Building headquarters in Vauxhall, Lambeth, London. A Russian-built RPG-22 anti-tank rocket, fired 300 metres (330 yards) away from MI6 headquarters, struck the building on the south side of the eighth floor, causing superficial damage. No fatalities or injuries were recorded.Although London had been the target of terrorist attacks before 2000, it had not been subjected to a rocket launcher attack; this was the first time a RPG-22 rocket launcher was seen and used in Great Britain. It was initially thought the Real IRA acquired the launchers from the Provisional IRA's arsenal, but later confirmed it was brought from the former Yugoslavia. The "audacious" attack caused minimal damage due to the building's bullet-proof and bomb-proof structure, failing to penetrate the inner cladding.At the time of the attack, the constituency of South Antrim was preparing for a by-election to be held the following day; it was won by Democratic Unionist William McCrea, who defeated Ulster Unionist David Burnside.

The Secret Intelligence Service (SIS), commonly known as MI6, is the foreign intelligence service of the United Kingdom, tasked mainly with the covert overseas collection and analysis of human intelligence in support of the UK's national security. SIS is one of the British intelligence agencies and the Chief of the Secret Intelligence Service ("C") is directly accountable to the Foreign Secretary.Formed in 1909 as the foreign section of the Secret Service Bureau, the section grew greatly during the First World War officially adopting its current name around 1920. The name "MI6" (meaning Military Intelligence, Section 6) originated as a convenient label during the Second World War, when SIS was known by many names. It is still commonly used today. The existence of SIS was not officially acknowledged until 1994. That year the Intelligence Services Act 1994 was introduced to Parliament, to place the organisation on a statutory footing for the first time. It provides the legal basis for its operations. Today, SIS is subject to public oversight by the Investigatory Powers Tribunal and the Intelligence and Security Committee of Parliament.The stated priority roles of SIS are counter-terrorism, counter-proliferation, providing intelligence in support of cyber security, and supporting stability overseas to disrupt terrorism and other criminal activities. Unlike its main sister agencies, Security Service (MI5) and Government Communications Headquarters (GCHQ), SIS works exclusively in foreign intelligence gathering; the ISA allows it to carry out operations only against persons outside the British Islands. Some of SIS's actions since the 2000s have attracted significant controversy, such as its alleged complicity in acts of enhanced interrogation techniques and extraordinary rendition.Since 1994, SIS headquarters have been in the SIS Building in London, on the South Bank of the River Thames.