Thomas Jefferson is appointed the first United States Secretary of State, John Jay is appointed the first Chief Justice of the United States, Samuel Osgood is appointed the first United States Postmaster General, and Edmund Randolph is appointed the first United States Attorney General.

John Jay (December 12, 1745 May 17, 1829) was an American statesman, patriot, diplomat, Founding Father, abolitionist, negotiator, and signatory of the Treaty of Paris of 1783. He served as the second governor of New York and the first chief justice of the United States. He directed U.S. foreign policy for much of the 1780s and was an important leader of the Federalist Party after the ratification of the United States Constitution in 1788.

Jay was born into a wealthy family of merchants and New York City government officials of French Huguenot and Dutch descent. He became a lawyer and joined the New York Committee of Correspondence, organizing American opposition to British policies such as the Intolerable Acts in the leadup to the American Revolution. Jay was elected to the First Continental Congress, where he signed the Continental Association, and to the Second Continental Congress, where he served as its president. From 1779 to 1782, Jay served as the ambassador to Spain; he persuaded Spain to provide financial aid to the fledgling United States. He also served as a negotiator of the Treaty of Paris, in which Britain recognized American independence. Following the end of the war, Jay served as Secretary of Foreign Affairs, directing United States foreign policy under the Articles of Confederation government. He also served as the first Secretary of State on an interim basis.

A proponent of strong, centralized government, Jay worked to ratify the United States Constitution in New York in 1788. He was a co-author of The Federalist Papers along with Alexander Hamilton and James Madison, and wrote five of the eighty-five essays. After the establishment of the new federal government, Jay was appointed by President George Washington the first Chief Justice of the United States, serving from 1789 to 1795. The Jay Court experienced a light workload, deciding just four cases over six years. In 1794, while serving as chief justice, Jay negotiated the highly controversial Jay Treaty with Britain. Jay received a handful of electoral votes in three of the first four presidential elections but never undertook a serious bid for the presidency.

Jay served as the governor of New York from 1795 to 1801. Although he successfully passed gradual emancipation legislation as governor of the state, he owned five slaves as late as 1800. In the waning days of President John Adams' administration, Jay was confirmed by the Senate for another term as chief justice, but he declined the position and retired to his farm in Westchester County, New York.

Thomas Jefferson (April 13, 1743 – July 4, 1826) was an American statesman, diplomat, lawyer, architect, philosopher, and Founding Father who served as the third president of the United States from 1801 to 1809. He had previously served as the second vice president of the United States under John Adams and as the first United States secretary of state under George Washington. The principal author of the Declaration of Independence, Jefferson was a proponent of democracy, republicanism, and individual rights, motivating American colonists to break from the Kingdom of Great Britain and form a new nation; he produced formative documents and decisions at both the state and national levels.

During the American Revolution, Jefferson represented Virginia in the Continental Congress that adopted the Declaration of Independence. As a Virginia legislator, he drafted a state law for religious freedom. He served as the second Governor of Virginia from 1779 to 1781, during the American Revolutionary War. In 1785, Jefferson was appointed the United States Minister to France, and subsequently, the nation's first secretary of state under President George Washington from 1790 to 1793. Jefferson and James Madison organized the Democratic-Republican Party to oppose the Federalist Party during the formation of the First Party System. With Madison, he anonymously wrote the provocative Kentucky and Virginia Resolutions in 1798 and 1799, which sought to strengthen states' rights by nullifying the federal Alien and Sedition Acts.

Jefferson was a longtime friend of John Adams, both serving in the Continental Congress and drafting the Declaration of Independence together. However, Jefferson's status as a Democratic-Republican would end up making Adams, a Federalist, his political rival. In the 1796 presidential election between Jefferson and Adams, Jefferson came second, which according to electoral procedure at the time, unintentionally elected him as vice president to Adams. Jefferson would later go on to challenge Adams again in 1800 and win the presidency. After concluding his presidency, Jefferson would eventually reconcile with Adams and shared a correspondence that lasted fourteen years.

As president, Jefferson pursued the nation's shipping and trade interests against Barbary pirates and aggressive British trade policies. Starting in 1803, Jefferson promoted a western expansionist policy, organizing the Louisiana Purchase which doubled the nation's claimed land area. To make room for settlement, Jefferson began the process of Indian tribal removal from the newly acquired territory. As a result of peace negotiations with France, his administration reduced military forces. Jefferson was re-elected in 1804. His second term was beset with difficulties at home, including the trial of former vice president Aaron Burr. In 1807, American foreign trade was diminished when Jefferson implemented the Embargo Act in response to British threats to U.S. shipping. The same year, Jefferson signed the Act Prohibiting Importation of Slaves.

Jefferson (while primarily a plantation owner, lawyer, and politician) mastered many disciplines, which ranged from surveying and mathematics to horticulture and mechanics. He was an architect in the classical tradition. Jefferson's keen interest in religion and philosophy led to his presidency of the American Philosophical Society; he shunned organized religion but was influenced by Christianity, Epicureanism, and deism. A philologist, Jefferson knew several languages. He was a prolific letter writer and corresponded with many prominent people, including Edward Carrington, John Taylor of Caroline and James Madison. Among his books is Notes on the State of Virginia (1785), considered perhaps the most important American book published before 1800. Jefferson championed the ideals, values, and teachings of the Enlightenment.

During his lifetime, Jefferson owned over 600 slaves, who were kept in his household and on his plantations. Since Jefferson's time, controversy has revolved around his relationship with Sally Hemings, a mixed-race enslaved woman, and his late wife's half-sister. According to DNA evidence from surviving descendants and oral history, Jefferson fathered at least six children with Hemings, including four that survived to adulthood. Evidence suggests that Jefferson started the relationship with Hemings when they were in Paris, some time after she arrived there at the age of 14 or 15, when Jefferson was 44. By the time she returned to the United States at 16 or 17, she was pregnant.After retiring from public office, Jefferson founded the University of Virginia. Jefferson and John Adams both died on July 4, 1826, the 50th anniversary of U.S. independence. Presidential scholars and historians generally praise Jefferson's public achievements, including his advocacy of religious freedom and tolerance in Virginia. Jefferson ranks highly among the U.S. presidents, usually in the top five.