James Meredith enters the University of Mississippi, defying segregation.

Racial segregation is the systematic separation of people into racial or other ethnic groups in daily life. Racial segregation can amount to the international crime of apartheid and a crime against humanity under the Statute of the International Criminal Court. Segregation can involve the spatial separation of the races, and mandatory use of different institutions, such as schools and hospitals by people of different races. Specifically, it may be applied to activities such as eating in restaurants, drinking from water fountains, using public toilets, attending schools, going to movies, riding buses, renting or purchasing homes or renting hotel rooms. In addition, segregation often allows close contact between members of different racial or ethnic groups in hierarchical situations, such as allowing a person of one race to work as a servant for a member of another race.

Segregation is defined by the European Commission against Racism and Intolerance as "the act by which a (natural or legal) person separates other persons on the basis of one of the enumerated grounds without an objective and reasonable justification, in conformity with the proposed definition of discrimination. As a result, the voluntary act of separating oneself from other people on the basis of one of the enumerated grounds does not constitute segregation". According to the UN Forum on Minority Issues, "The creation and development of classes and schools providing education in minority languages should not be considered impermissible segregation if the assignment to such classes and schools is of a voluntary nature."Racial segregation has generally been outlawed worldwide. In the United States, racial segregation was mandated by law in some states (see Jim Crow laws) and enforced along with anti-miscegenation laws (prohibitions against interracial marriage), until the U.S. Supreme Court led by Chief Justice Earl Warren struck down racial segregationist laws throughout the United States. However, racial segregation may exist de facto through social norms, even when there is no strong individual preference for it, as suggested by Thomas Schelling's models of segregation and subsequent work. Segregation may be maintained by means ranging from discrimination in hiring and in the rental and sale of housing to certain races to vigilante violence (such as lynchings). Generally, a situation that arises when members of different races mutually prefer to associate and do business with members of their own race would usually be described as separation or de facto separation of the races rather than segregation.

James Howard Meredith (born June 25, 1933) is the first African-American student admitted to the racially segregated University of Mississippi. He is also an American civil rights movement figure, writer, political adviser, and Air Force veteran. It was in 1962 that Meredith became the first African-American student admitted to the theretofore segregated University of Mississippi, after the intervention of the federal government, an event that was a flashpoint in the civil rights movement. Inspired by President John F. Kennedy's inaugural address, Meredith decided to exercise his constitutional rights and apply to the University of Mississippi. His goal was to put pressure on the Kennedy administration to enforce civil rights for African Americans.In 1966, Meredith planned a solo 220-mile March Against Fear from Memphis, Tennessee, to Jackson, Mississippi; he wanted to highlight continuing racism in the South and encourage voter registration after passage of the Voting Rights Act of 1965. He did not want major civil rights organizations involved. The second day, he was shot by a white gunman and suffered numerous wounds. Leaders of major organizations vowed to complete the march in his name after he was taken to the hospital. While Meredith was recovering, more people from across the country became involved as marchers. He rejoined the march and when Meredith and other leaders entered Jackson on June 26, they were leading an estimated 15,000 marchers, in what was the largest civil rights march in Mississippi. During the march, more than 4,000 African Americans registered to vote, and it was a catalyst to continued community organizing and additional registration.

In 2002 and again in 2012, the University of Mississippi led year-long series of events to celebrate the 40th and 50th anniversaries of Meredith's integration of the institution. He was among numerous speakers invited to the campus, where a statue of him commemorates his role. The Lyceum-The Circle Historic District at the center of the campus has been designated as a National Historic Landmark for these events.