The Wilkes Expedition, which would explore the Puget Sound and Antarctica, weighs anchor at Hampton Roads.

Puget Sound () is a sound of the Pacific Northwest, an inlet of the Pacific Ocean, and part of the Salish Sea. It is located along the northwestern coast of the U.S. state of Washington. It is a complex estuarine system of interconnected marine waterways and basins, with one major and two minor connections to the open Pacific Ocean via the Strait of Juan de FucaAdmiralty Inlet being the major connection and Deception Pass and Swinomish Channel being the minor.

Water flow through Deception Pass is approximately equal to 2% of the total tidal exchange between Puget Sound and the Strait of Juan de Fuca. Puget Sound extends approximately 100 miles (160 km) from Deception Pass in the north to Olympia in the south. Its average depth is 450 feet (140 m) and its maximum depth, off Jefferson Point between Indianola and Kingston, is 930 feet (280 m). The depth of the main basin, between the southern tip of Whidbey Island and Tacoma, is approximately 600 feet (180 m).In 2009, the term Salish Sea was established by the United States Board on Geographic Names as the collective waters of Puget Sound, the Strait of Juan de Fuca, and the Strait of Georgia. Sometimes the terms "Puget Sound" and "Puget Sound and adjacent waters" are used for not only Puget Sound proper but also for waters to the north, such as Bellingham Bay and the San Juan Islands region.The term "Puget Sound" is used not just for the body of water but also the Puget Sound region centered on the sound. Major cities on the sound include Seattle, Tacoma, Olympia, and Everett. Puget Sound is also the second-largest estuary in the United States, after Chesapeake Bay in Maryland and Virginia.

The United States Exploring Expedition of 1838–1842 was an exploring and surveying expedition of the Pacific Ocean and surrounding lands conducted by the United States. The original appointed commanding officer was Commodore Thomas ap Catesby Jones. Funding for the original expedition was requested by President John Quincy Adams in 1828, however, Congress would not implement funding until eight years later. In May 1836, the oceanic exploration voyage was finally authorized by Congress and created by President Andrew Jackson.

The expedition is sometimes called the U.S. Ex. Ex. for short, or the Wilkes Expedition in honor of its next appointed commanding officer, United States Navy Lieutenant Charles Wilkes. The expedition was of major importance to the growth of science in the United States, in particular the then-young field of oceanography. During the event, armed conflict between Pacific islanders and the expedition was common and dozens of natives were killed in action, as well as a few Americans.