The Emperor Krishnadevaraya ascends to the throne, marking the beginning of the regeneration of the Vijayanagara Empire.

The Vijayanagara Empire, also called the Karnata Kingdom, was based in the Deccan Plateau region of South India. It was established in 1336 by the brothers Harihara I and Bukka Raya I of the Sangama dynasty, members of a pastoralist cowherd community that claimed Yadava lineage. The empire rose to prominence as a culmination of attempts by the southern powers to ward off Turkic Islamic invasions by the end of the 13th century. At its peak, it subjugated almost all of South India's ruling families and pushed the sultans of the Deccan beyond the Tungabhadra-Krishna river doab region, in addition to annexing modern day Odisha (ancient Kalinga) from the Gajapati Kingdom thus becoming a notable power. It lasted until 1646, although its power declined after a major military defeat in the Battle of Talikota in 1565 by the combined armies of the Deccan sultanates. The empire is named after its capital city of Vijayanagara, whose ruins surround present day Hampi, now a World Heritage Site in Karnataka, India. The wealth and fame of the empire inspired visits by and writings of medieval European travelers such as Domingo Paes, Ferno Nunes, and Niccol de' Conti. These travelogues, contemporary literature and epigraphy in the local languages and modern archeological excavations at Vijayanagara has provided ample information about the history and power of the empire.

The empire's legacy includes monuments spread over South India, the best known of which is the group at Hampi. Different temple building traditions in South and Central India were merged into the Vijayanagara architecture style. This synthesis inspired architectural innovations in the construction of Hindu temples. Efficient administration and vigorous overseas trade brought new technologies to the region such as water management systems for irrigation. The empire's patronage enabled fine arts and literature to reach new heights in Kannada, Telugu, Tamil, and Sanskrit with topics such as astronomy, mathematics, medicine, fiction, musicology, historiography and theater gaining popularity. The classical music of Southern India, Carnatic music, evolved into its current form. The Vijayanagara Empire created an epoch in the history of Southern India that transcended regionalism by promoting Hinduism as a unifying factor.

Krishnadevaraya was a medieval Indian emperor of the Vijayanagara Empire, who reigned from 1509 to 1529. He was the third ruler of the Tuluva dynasty. He ruled the largest empire in India after the decline of the Delhi Sultanate. Presiding over the empire at its zenith, he is regarded as an icon by many Indians. Krishnadevaraya earned the titles Karnatakaratna simhasanadeeshwara (lit. "Lord of the Jewelled Throne of Karnataka"), Yavvana raja pratistaphanacharya (lit. "Establishment of young king to Bahmani throne"), Kannada Rajya Rama Ramana (lit. "Lord of the Kannada empire), Andhra Bhoja (lit. "Scholar of Andhra"), Gaubrahmana Pratipalaka (lit. "Protector of Brahmins and Cow") and Mooru Rayara Ganda (lit. "Lord of three kings"). He became the dominant ruler of the peninsula by defeating the sultans of Bijapur, Golconda, the Bahmani Sultanate and the Gajapatis of Odisha, and was one of the most powerful Hindu rulers in India. When the Mughal Emperor Babur was taking stock of the potentates of north India, he rated Krishnadevaraya the most powerful, with the most extensive empire in the subcontinent.

He earned the titles of 'Kannada Rajya Rama Ramana', 'Andhra Bhoja' and 'Mooru Rayara Ganda'.Portuguese travellers Domingo Paes and Fernao Nuniz visited the Vijayanagara Empire during his reign. Travelogues indicate that the king was not only an able administrator but also an excellent general, leading from the front in battle and even attending to the wounded. On many occasions, the king changed battle plans abruptly, turning a losing battle into victory. The poet Muku Timmana praised him as the destroyer of the Turks. Krishnadevaraya benefited from an able prime minister Timmarusu, whom he regarded as a father figure responsible for his coronation. Krishnadevaraya was well advised by the witty Tenali Ramakrishna.