Spanish Jesuit missionaries land in present-day Virginia to establish the short-lived Ajacán Mission.

The Ajacn Mission (Spanish pronunciation: [axakan]) (also Axaca, Axacam, Iacan, Jacn, Xacan) was a Spanish attempt in 1570 to establish a Jesuit mission in the vicinity of the Virginia Peninsula to bring Christianity to the Virginia Indians. The effort to found St. Mary's Mission predated the founding of the English settlement at Jamestown, Virginia, by about 36 years. In February 1571, the entire party was massacred by Indians except for Alonso de Olmos. The following year, a Spanish party from Florida went to the area, rescued Alonso, and killed an estimated 20 Indians.

The Society of Jesus (Latin: Societas Iesu; abbreviated SJ), also known as the Jesuits (; Latin: Iesuitæ), is a religious order of the Catholic Church headquartered in Rome. It was founded by Ignatius of Loyola and six companions with the approval of Pope Paul III in 1540. The society is engaged in evangelization and apostolic ministry in 112 nations. Jesuits work in education, research, and cultural pursuits. Jesuits also give retreats, minister in hospitals and parishes, sponsor direct social ministries, and promote ecumenical dialogue.

The Society of Jesus is consecrated under the patronage of Madonna Della Strada, a title of the Blessed Virgin Mary, and it is led by a Superior General. The headquarters of the society, its General Curia, is in Rome. The historic curia of Ignatius is now part of the Collegio del Gesù attached to the Church of the Gesù, the Jesuit mother church.

Members of the Society of Jesus are expected to accept orders to go anywhere in the world, where they might be required to live in extreme conditions. This was so because Ignatius, its leading founder, was a nobleman who had a military background. Accordingly, the opening lines of the founding document declared that the society was founded for "whoever desires to serve as a soldier of God, to strive especially for the defence and propagation of the faith, and for the progress of souls in Christian life and doctrine". Jesuits are thus sometimes referred to colloquially as "God's soldiers", "God's marines", or "the Company". The society participated in the Counter-Reformation and, later, in the implementation of the Second Vatican Council.