Flying Tiger Line Flight 739 was a Lockheed L-1049 Super Constellation propliner chartered by the United States military that disappeared on March 16, 1962, over the Western Pacific Ocean. The aircraft was transporting 93 U.S. soldiers and three South Vietnamese from Travis Air Force Base, California to Saigon, Vietnam. After refueling at Andersen Air Force Base, Guam, the Super Constellation was en route to Clark Air Base in the Philippines when it disappeared. All 107 aboard were declared missing and presumed dead.

The airliner's disappearance prompted one of the largest air and sea searches in the history of the Pacific. Aircraft and surface ships from four branches of the U.S. military searched more than 144,000 square miles (370,000 km2) during the course of eight days. A civilian tanker observed what appeared to be an in-flight explosion believed to be the missing Super Constellation, though no trace of wreckage or debris was ever recovered. The Civil Aeronautics Board determined that, based on the tanker's observations, Flight 739 probably exploded in-flight, though an exact cause could not be determined without examining the remnants of the aircraft. This was the worst aviation accident involving the Lockheed Constellation.

Flying Tiger Line, also known as Flying Tigers, was the first scheduled cargo airline in the United States and a major military charter operator during the Cold War era for both cargo and personnel (the latter with leased aircraft). The airline was bought by Federal Express in 1988.