Rodrigo de Castro Osorio, Spanish cardinal (d. 1600)
Rodrigo de Castro Osorio, (Valladolid, March 5, 1523 – Seville, 1600) was Cardinal-Bishop of Zamora (1574–1578) and Diocese of Cuenca (1578–1581), Archbishop of Seville, (1581–1600), a member of the Council of State of Spain and the Supreme Council of the Spanish Inquisition for the reign of Philip II of Spain. Great-uncle of Pedro Fernández de Castro y Andrade, Conde de Lemos. He was closely linked to the city of Monforte de Lemos in Galicia, where he was the founder of the College of Our Lady of Antigua.